Hexylamine → N-(4-dimethylamino-6-hexylaminopyrimidin-5-yl)-2-hexylaminodecanamide

HRID 2379639Notes

Reaction equation

HRID 2379639 reaction equation
[NH2:1][C:2]1[C:3]([N:9]([CH3:11])[CH3:10])=[N:4][CH:5]=[N:6][C:7]=1Cl.Br[CH:13]([CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH3:24])[C:14]([OH:16])=O.[CH2:25]([NH2:31])[CH2:26][CH2:27][CH2:28][CH2:29][CH3:30]>>[CH3:10][N:9]([CH3:11])[C:3]1[C:2]([NH:1][C:14](=[O:16])[CH:13]([NH:31][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH3:30])[CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH3:24])=[C:7]([NH:31][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH3:30])[N:6]=[CH:5][N:4]=1

Participants

4

Reactant 3

HCID 8102HexylamineHCID 983102-Bromodecanoic acidHCID 7689556-Chloro-N4,N4-dimethylpyrimidine-4,5-diamine

Product 1

HCID 19027874N-(4-dimethylamino-6-hexylaminopyrimidin-5-yl)-2-hexylaminodecanamide

Procedure

5-Amino-4-(dimethyl)amino-6-chloropyrimidine (prepared as described in Example 257) was coupled with 2-bromodecanoic acid using the procedure described in Example 249, followed by the addition of n-hexylamine as described in Example 250 to give the title compound.

Sources & evidence

ORD record
ord-6a6ccadbc90943da95d9c8cc66b46a20
Source dataset
uspto-grants-1994_11
Patent number
US05362878

Reaction notes

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