Methanol → Methyl L-phenylalaninate hydrochloride

Participants

Reaction Steps

A 400 g (2.42 mol) sample of L-phenylalanine was slurried in 4 L of MeOH. To this was slowly added 240 mL of thionyl chloride, the temperature was allowed to increase, and the solution held at reflux for 16 hours. The solvent was removed to afford the title product as a white solid. The compound was taken directly to the next step.

Provenance & Evidence