Sodium Methoxide → HCID 18955697, compound

HRID 2379647Notes

Reaction equation

HRID 2379647 reaction equation
C[O-].[Na+].Cl[CH2:5][CH2:6][O:7][C:8]([NH:10][C:11]1[CH:19]=[C:18]2[C:14]([CH:15]=[CH:16][NH:17]2)=[CH:13][CH:12]=1)=[O:9]>CO>[NH:17]1[C:18]2[C:14](=[CH:13][CH:12]=[C:11]([N:10]3[CH2:5][CH2:6][O:7][C:8]3=[O:9])[CH:19]=2)[CH:15]=[CH:16]1

Participants

4

Reactant 2

HCID 10942334Sodium MethoxideHCID 18955693HCID 18955693, compound

Product 1

HCID 18955697HCID 18955697, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent2×

Procedure

60 ml of methanol are added to 120 ml of a 30% solution of sodium methylate in methanol and 0.25 mol (60 g) of 6-(β-chloroethoxycarbonyl)aminoindole (prepared in accordance with the first step of Example 1) are then added, with stirring. The temperature reaches 50° C. Stirring is continued for 15 minutes after the end of the addition. The precipitate formed is drained, washed with alcohol and then dried. It melts at 199° C.

Workup

  1. customprepared in accordance with the first step of Example 1)
  2. additionare then added
  3. customreaches 50° C
  4. stirringStirring
  5. additionafter the end of the addition
  6. customThe precipitate formed
  7. washwashed with alcohol
  8. customdried

Sources & evidence

ORD record
ord-2cd971e7d6814e20a09962f339014a87
Source dataset
uspto-grants-1994_11
Patent number
US05364414

Reaction notes

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