HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Bicarbonate → 6-Chloro-5-methyl-3-phenyl-1,7-naphthyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Reactant | 3-[2-Chloro-3-methyl-5-pivaloylamino-4-pyridyl]-1,1-diethoxy-2-hydroxy-2-phenylpropane | HCID 10411410 | — |
| Solvent | Hydrochloric Acid | HCID 313 | — |
| Product | 6-Chloro-5-methyl-3-phenyl-1,7-naphthyridine | HCID 9992507 | — |
Reaction Steps
180.5 g (0.4 mol) of finely divided compound from Example I are intensively stirred under reflux for 5 h in 2.6 l of 2N HCl using a mechanical stirrer. The mixture is then neutralised with NaHCO3 and extracted several times with ethyl acetate, and the extracts are dried. 37.6 g of the title compound are obtained by crystallisation. Chromatography of the mother liquor (silica gel, toluene→toluene/ethyl acetate 2:1) yields a further 23.14 g of the title compound. Total yield: 60% M.p.: 136° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05364855 |
| Source dataset | uspto-grants-1994_11 |
| ORD ID | ord-817c21cae54f45b48cf0cea7e82f0ffc |
| Source note | uspto-grants-1994_11 |