反应详情

33.7 g (132 mmol) of the compound from Example II are dissolved in 600 ml of ethanol, the solution is treated with 293 ml of 1N NaOH and 10 g of 5% Pd/C and the mixture is immediately hydrogenated in the Parr apparatus at 3 bar for 30 min. It is filtered through kieselguhr and the ethanol content is evaporated in vacuo. The product precipitated in this way is filtered off with suction, washed with plenty of water and then with ether and dried. Yield: 23.6 g (81.2%) M.p.: 135°-138° C.

1. filtrationIt is filtered through kieselguhr
2. customthe ethanol content is evaporated in vacuo
3. customThe product precipitated in this way
4. filtrationis filtered off with suction
5. washwashed with plenty of water
6. dry with materialwith ether and dried