Sodium Hydroxide → HCID 18956132, compound

Participants

Reaction Steps

12 g (47.2 mmol) of the compound from Example VII are hydrogenated for several hours at 3 bar in the Parr apparatus in 400 ml of dioxane and 75 ml of 1N NaOH in the presence of 1.5 g of Pd-C (5% strength) with TLC checking. Solid is then filtered off with suction through kieselguhr and the filtrate is concentrated on a rotary evaporator. After chromatography on silica gel (toluene→toluene/ethyl acetate 1:1), 1.8 g (17%) of the pure title compound are obtained. M.p.: 101° C.

Provenance & Evidence