Ethanol → HCID 18956198, compound

Participants

Reaction Steps

9.3 g Ethyl 1-(3-phenylpropyl)-4-phenyl-4-piperidine-carboxylate (Formula I: R1 =hydrogen, R2 =COOEt, X=Y=CH2), prepared according to the procedure described in U.S. Pat. No. 2,914,532, incorporated herein by reference, was taken up in 35 ml water and 12 ml ethanol with 2.3 g sodium hydroxide, then refluxed for 24 hours and stirred at room temperature for the next two days. The product mixture was poured into water, the solution was acidified with acetic acid, and a precipitate appeared. The precipitate was washed well with water. The product was recrystallized from 4 liters of water and was washed with water, ethanol and ether, yielding 4-phenyl-1-(3-phenylpropyl)-4-piperidinecarboxylic acid, as a white powder, which was used without further purification in the next preparation.

Provenance & Evidence