Sodium Carbonate → HCID 15232702, compound

Participants

Reaction Steps

3 g 4-benzoyl-4-phenylpiperidine was taken up in 200 ml n-butanol with 1.5 ml 1-bromo-3-phenylpropane and 10 g sodium carbonate, and refluxed for 4 hours. The resulting mixture was filtered and the filtrate concentrated in vacuo, taken up in ethyl acetate and washed with water. The ethyl acetate layer was dried over potassium carbonate and eluted through a short silica plug with 1:1 hexane/ethyl acetate. The eluted product was concentrated to dryness overnight, giving 3.14 g of product, melting point: 185°-186° C.

Provenance & Evidence