Linalool → HCID 86748244, compound

HRID 2379769Notes

Reaction equation

HRID 2379769 reaction equation
CC(C)(CNC(C[C@@H]1CC[C@]2(O[C:15]3([CH:21]4CC5CC(C4)CC3C5)[O:14][O:13]2)CC1)=O)N.[CH2:29]=[CH:30][C:31]([CH2:34][CH2:35][CH:36]=[C:37]([CH3:39])[CH3:38])([CH3:33])[OH:32]>>[O:32]1[CH2:21][CH2:15][O:14][O:13]1.[CH2:29]=[CH:30][C:31]([CH2:34][CH2:35][CH:36]=[C:37]([CH3:39])[CH3:38])([CH3:33])[OH:32]

Participants

3

Reactant 2

HCID 6549LinaloolHCID 178457566HCID 178457566, compound

Product 1

HCID 86748244HCID 86748244, compound

Procedure

A culture of E.coli was harvested with sterile saline using swabs. The number of Colony Forming Units (CFUs) per ml in the suspension was determined by Standard Plate Count Method. A working suspension of E. coli with approximately 1.0×107CFUs/ 0.1 ml was then prepared. Four aliquots of 1 ml of test ointment containing 1.0% trioxolane or diperoxide derivative of linalool were removed and place in separate sterile screw-capped tubes. Each sample was inoculated with 0.1 ml of the working suspension of E. coli to yield a final concentration of approximately 1×106 CFUs/1 ml of the product. The samples were stored at 20°-25° C. for a total of 28 days. Samples were selected at 7 day intervals to determine the number of viable CFUs present. A control with uninoculated ointment was also stored with samples selected at the same intervals. At 7 days, and all subsequent sample selections, there were less than 10 CFUs present. No CFUs were present in any control sample.

Workup

  1. customThe number of Colony Forming Units (CFUs) per ml in the suspension
  2. additionA working suspension of E
  3. customcoli with approximately 1.0×107CFUs/ 0.1 ml was then prepared
  4. customwere removed
  5. customplace in separate sterile screw-capped tubes

Sources & evidence

ORD record
ord-056c1b6679064bb6bf9bb046e150282d
Source dataset
uspto-grants-1994_11
Patent number
US05364879

Reaction notes

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