反应详情

温度

25 °C

The crude cyanomethylbenzofuran, compound 6, was stirred for 6 hours in boiling water (1,000 ml) containing sodium hydroxide (80 g), cooled to 25° C., then washed with methylene chloride (250 ml, then 2×100 ml). The pH was brought to 2.0 with 6N HCl. The precipitate was extracted with methylene chloride (200 ml, then 100 ml, then 50 ml), dried over magnesium sulfate and the solvent evaporated. The yield was approximately 72 g.

1. washwashed with methylene chloride (250 ml
2. extractionThe precipitate was extracted with methylene chloride (200 ml
3. dry with material100 ml, then 50 ml), dried over magnesium sulfate
4. customthe solvent evaporated