Water → HCID 20325024, compound

HRID 2379778Notes

Reaction equation

HRID 2379778 reaction equation
[C:1]([CH2:3][C:4]1[O:5][C:6]2[CH:12]=[CH:11][CH:10]=[CH:9][C:7]=2[CH:8]=1)#N.[OH-:13].[Na+].[OH2:15]>>[C:4]1([CH2:3][C:1]([OH:15])=[O:13])[O:5][CH:6]=[C:12]2[CH:11]=[CH:10][CH:9]=[CH:7][C:8]=12

Participants

4

Reactant 3

HCID 962WaterHCID 14798Sodium HydroxideHCID 15618732HCID 15618732, compound2×

Product 1

HCID 20325024HCID 20325024, compound

Conditions

Temperature
25 °C

Procedure

The crude cyanomethylbenzofuran, compound 6, was stirred for 6 hours in boiling water (1,000 ml) containing sodium hydroxide (80 g), cooled to 25° C., then washed with methylene chloride (250 ml, then 2×100 ml). The pH was brought to 2.0 with 6N HCl. The precipitate was extracted with methylene chloride (200 ml, then 100 ml, then 50 ml), dried over magnesium sulfate and the solvent evaporated. The yield was approximately 72 g.

Workup

  1. washwashed with methylene chloride (250 ml
  2. extractionThe precipitate was extracted with methylene chloride (200 ml
  3. dry with material100 ml, then 50 ml), dried over magnesium sulfate
  4. customthe solvent evaporated

Sources & evidence

ORD record
ord-12b9dadcd5b440c093ebc40fde054ccf
Source dataset
uspto-grants-1994_11
Patent number
US05364880

Reaction notes

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