Dimethyl Sulfoxide → HCID 14210538, compound

Participants

Reaction Conditions

Reaction Steps

4,3 g (0.0097 mole) of 3-bromo-3,4-dihydro-2,2-dimethyl-7-methoxy-6-(p-tolylsulfonyl)-2H-benzo[b]pyran-4-ol are dissolved in 28 ml of dimethyl sulfoxide, and 3.5 ml of 2-pyrrolidinone (0.0465 mole) and 0.78 g of sodium hydride (80% suspension in oil) (0.0325 mole) are added, and the mixture is stirred at 40° C. for 3 hours. It is left to stand overnight and then poured onto ice-water and filtered with suction. The precipitate is recrystallized from isopropanol. White crystals of melting point: 263°-65° C.

Provenance & Evidence