反应详情

A mixture of 2-bromo-1-hydroxy-3-oxo-1-butene (9.61 g) and N-[(thiocarbamoyl)methyl]acetamide (7.70 g) in acetone (100 ml) was refluxed for one hour with stirring. The resulting precipitate was collected by filtration and chromatographed on silica gel eluting with a mixture of chloroform and methanol (20:1, V/V) to give 5-acetyl-2-(acetylaminomethyl)thiazole (3.48 g).

1. temperaturewas refluxed for one hour
2. filtrationThe resulting precipitate was collected by filtration
3. customchromatographed on silica gel eluting with a mixture of chloroform and methanol (20:1, V/V)