Acetic Anhydride → HCID 10330249, compound

Participants

Reaction Steps

A mixture of 6-hydroxymethyl-2-pyridinecarboxamide (80 g) and acetic anhydride (198.8 ml) in tetrahydrofuran (800 ml) was heated under reflux for 24 hours. The reaction mixture was added to a mixture of ethyl acetate and water and the mixture was adjusted to pH 8 with potassium carbonate. The separated organic layer was washed with brine, dried over magnesium sulfate and evaporated to give 6 -acetoxymethyl-2-pyridinecarboxamide (93.34 g).

Provenance & Evidence