HuagongsheHuagongshe Chemistry Print Report · For research reference only
Bromine → 5-Bromoacetyl-3-pyridinecarboxylic acid methyl ester hydrobromide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Bromine | HCID 24408 | — |
| Reactant | Methyl 5-acetylpyridine-3-carboxylate | HCID 596459 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 5-Bromoacetyl-3-pyridinecarboxylic acid methyl ester hydrobromide | HCID 88442364 | 157.1% |
Reaction Steps
Bromine (6.0 g) was added slowly to a solution of 5-acetyl-3-pyridinecarboxylic acid methyl ester (6.0 g) in dioxane (50 ml) at room temperature. The mixture was stirred at room temperature for 1 hour and then heated at 60°-70° C. for 5 hours. The resulting precipitate was collected by filtration to afford 5-bromoacetyl-3-pyridinecarboxylic acid methyl ester hydrobromide (10.0 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05364871 |
| Source dataset | uspto-grants-1994_11 |
| ORD ID | ord-4a166fb01880464d82667aabe0a42c1a |
| Source note | uspto-grants-1994_11 |