反应详情

A suspension of 2-(diaminomethyleneamino)-4-(5-methoxycarbonylpyridin-3-yl)thiazole (2.0 g), cyclopentylamine (3.7 g) and 28% sodium methoxide methanolic solution (5 ml) in methanol (50 ml) was refluxed for 2 hours. The solvent was removed under reduced pressure. The residue was dissolved in water (50 ml). The mixture was extracted with a mixture of ethyl acetate (150 ml) and tetrahydrofuran (50 ml). The extract was dried over magnesium sulfate and then was evaporated. Recrystallization from a mixture of methanol and diisopropyl ether afforded 4-(5-cyclopentylaminocarbonylpyridin-3-yl)-2-(diaminomethyleneamino)thiazole (0.2 g).

1. temperaturewas refluxed for 2 hours
2. customThe solvent was removed under reduced pressure
3. dissolutionThe residue was dissolved in water (50 ml)
4. extractionThe mixture was extracted with a mixture of ethyl acetate (150 ml) and tetrahydrofuran (50 ml)
5. dry with materialThe extract was dried over magnesium sulfate
6. customwas evaporated
7. customRecrystallization
8. additionfrom a mixture of methanol and diisopropyl ether