1,4-Dibromobutane → 4-[4-(6-Fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]butylbromide

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Reaction Steps

A mixture of 6-fluoro-3-(4-piperidinyl)-1,2-benzisoxazole (12 in, 55 mmol), K2CO3 (13 m) and 1,4-dibromobutane (20 m, 9.3 mmol, 1.7 eq) in acetonitrile (300 ml) was stirred at room temperature overnight. The inorganic material was filtered. The solution was concentrated to ~ 80 ml, when crystals crashed out. The product was filtered to yield 14.16 m (73%), m.p.=243°-245° C.

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