HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,3-Isobenzofurandione, 5-fluoro- → N-[2-[4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-4-fluorophthalimide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,3-Isobenzofurandione, 5-fluoro- | HCID 67572 | — |
| Reactant | 2-(4-(6-Fluorobenzo[d]isoxazol-3-yl)piperidin-1-yl)ethan-1-amine | HCID 14699857 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | N-[2-[4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-4-fluorophthalimide | HCID 15378691 | — |
Reaction Steps
A stirred mixture of 2-[4-(6-fluoro-1,2-benzisoxazol-3-yl)-1piperidinyl]ethylamine (2.63 g, 0.01 mole) and 4-fluorophthalic anhydride (1.83 g, 0.011 mole) in dichloromethane (100 ml) is stirred at room temperature for 4 hours. The solvent is then removed under reduced pressure and the residual solids are purified by flash chromatography. The product is further purified by recrystallization to afford N-[2-[4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-4-fluorophthalimide.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05364866 |
| Source dataset | uspto-grants-1994_11 |
| ORD ID | ord-3927869b0304434da6de55afc8215d85 |
| Source note | uspto-grants-1994_11 |