反应详情

64.6 g (0.25 mol) of 3-trifluoromethyl-4-methylbenzenesulphonyl chloride are taken up in 500 ml of carbon tetrachloride and, after addition of 44.5 g (0.25 mol) of N-bromosuccinimide and 0.4 g of ABN, the mixture is heated under reflux for 24 hours. After cooling, the solids are filtered off and the filtrate is freed from the solvent. Flash chromatography using petroleum ether/toluene (4:1), 50 μm particle size, gives 33.9 g (40% of theory) of the title compound.

1. temperaturethe mixture is heated
2. temperatureunder reflux for 24 hours
3. temperatureAfter cooling
4. filtrationthe solids are filtered off