HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diethyl Ether → HCID 18956540, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diethyl Ether | HCID 3283 | — |
| Reactant | 3-Methylpyridazine | HCID 74208 | — |
| Reactant | Lithium diisopropylamide | HCID 2724682 | — |
| Reactant | Methyl 2,4-Difluorobenzoate | HCID 2782897 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 18956540 | HCID 18956540 | 29.1% |
Reaction Steps
Treatment of 3-methylpyridazine (4.70 g) with lithium diisopropylamide (0.05 mole) in dry tetrahydrofuran followed by methyl 2,4-difluorobenzoate (8.60 g) according to the method of Example 11(i) gave the title compound, (3.40 g), m.p. 115.5°-117.5° (from ether).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05364938 |
| Source dataset | uspto-grants-1994_11 |
| ORD ID | ord-53df6edc28bc43708befd6370fb784d1 |
| Source note | uspto-grants-1994_11 |