HuagongsheHuagongshe Chemistry Print Report · For research reference only
Oxalyl chloride → 3-Fluoro-5-methoxybenzoyl chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Oxalyl chloride | HCID 65578 | — |
| Reactant | 3-Fluoro-5-methoxybenzoic acid | HCID 21942469 | — |
| Catalyst | Dimethylformamide | HCID 6228 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 3-Fluoro-5-methoxybenzoyl chloride | HCID 86617014 | — |
Reaction Steps
3-fluoro-5-methoxybenzoic acid (5 g, 0.029 mol) was stirred in CH2Cl2 (50 ml) at 0° C. under an argon atmosphere. DMF (9 drops, catalytic) was added, followed by oxalyl chloride (12.7 ml, 0.147 mol). Reaction was warmed to room temperature then stirred under argon for one hour. Reaction was concentrated in vacuo to yield 3-fluoro-5-methoxybenzoyl chloride (BA67).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08642604B2 |
| Source dataset | uspto-grants-2014_02 |
| ORD ID | ord-81bed34386834e2b92b6b3f50f89cbd0 |
| Source note | uspto-grants-2014_02 |