HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2380076Generated: October 30, 2026
Hydrochloric Acid → 4-Chloro-2'-nitrobutyrophenone
https://huagongshe.com/reaction/2380076
Participants
| Role | Name | HCID | Charge |
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| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | o-nitrobenzoyl-2(3H)-furanone | HCID 15766854 | — |
| Product | 4-Chloro-2'-nitrobutyrophenone | HCID 11806412 | 95% |
Reaction Steps
A mixture of dihydro-3-(o-nitrobenzoyl-2(3H)-furanone (2.0 g, 8.5 mmole) in 10 g of 37% HCl solution is stirred at 70° C. until reaction is complete by TLC, cooled to room temperature and extracted with toluene. The organic extracts are combined and concentrated in vacuo to give the title product as a golden oil, 1.84 g (95% yield), 99% pure by HPLC analysis, identified by 1HNMR.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05364968 |
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| Source dataset | uspto-grants-1994_11 |
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| ORD ID | ord-88200e3d98524546b929cc420a52eb75 |
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| Source note | uspto-grants-1994_11 |
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