反应详情

A stirred mixture of 4-bromo-2'-nitrobutyrophenone (3.44 g, 0.013 mole) and NaOH (0.76 g, 0.019 mole) in water is heated at reflux temperature until reaction is complete by TLC, cooled to room temperature and extracted with diethyl ether. The ether extracts are combined, dried over Na2SO4 and concentrated in vacuo to give a dark brown liquid residue. The residue is taken up in diethyl ether, filtered through silica gel and concentrated in vacuo to give the title product as a yellow oil, identified by 1HNMR.

1. temperatureis heated
2. temperatureat reflux temperature
3. customuntil reaction
4. extractionextracted with diethyl ether
5. dry with materialdried over Na2SO4
6. concentrationconcentrated in vacuo
7. customto give a dark brown liquid residue
8. filtrationfiltered through silica gel
9. concentrationconcentrated in vacuo