HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 4-Chloro-2'-nitrobutyrophenone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 2(3H)-Furanone, dihydro-3-(2-nitrobenzoyl)- | HCID 591740 | — |
| Product | 4-Chloro-2'-nitrobutyrophenone | HCID 11806412 | — |
Reaction Steps
The 18% solution of dihydro-3-(o-nitrobenzoyl)-2(3H)furanone in toluene obtained in Example 5 (450 g, 0.34 mole furanone) is treated, with stirring, with 37% HCl (48 g, 0.60 mole HCl), heated at reflux temperature for 6-11 hours, until reaction is complete by LC analysis, cooled to 35°-45° C. and allowed to settle. The phases are separated to give the title product as a toluene solution, 425 g. The product solution is used as is in Example 7.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05364968 |
| Source dataset | uspto-grants-1994_11 |
| ORD ID | ord-db90d4039e694d45b966cf2b6001e7c5 |
| Source note | uspto-grants-1994_11 |