Toluene → HCID 131718736, compound

Participants

Reaction Steps

To a mixture of 230 g (0,667 mol) of 2-[2-bromo-4-(3,5-difluorophenoxy)phenoxy]ethylamine, 81 g (0.80 mol) of triethylamine and 8 liter of toluene, there is added dropwise a solution of 70 g (0.67 mol) of cyclopropane carbonyl chloride in 2 liter of toluene with stirring at a temperature of from 5° C. to 10° C. After 2 hours, the reaction mixture is stirred at a room temperature for 15 hours. After the reaction is completed, the resultant mixture is washed twice with water, dried over anhydrous magnesium sulfate and concentrated under reduced pressure. The residue is subjected to silica gel chromatography to give N-{2-[2-bromo-4-(3,5-difluorophenoxy)phenoxy]ethyl}-cyclopropane carboxyamide.

Provenance & Evidence