Triethylamine → (2S, 4S, 5S)-5-{N-[2(R)-(1-Naphthylmethyl)-3-(morpholinocarbonyl)propionyl]-3-(4-thiazolyl)-L-alanyl}amino-4-hydroxy-2-(1-hydroxy-1-methylethyl)-7-methyl-N-methyloctanamide

Participants

Reaction Steps

4S, 5S)-5-[N-(t-butoxycarbonyl)-3-(4-thiazolyl)-L-alanyl]amino-4-hydroxy-2-(1-hydroxy-1-methylethyl)-7-methyl-N-methyl octanamide [prepared as described in Example 16(a)], 119 mg (0.36 mmoles) of 2(R)-(1-naphthylmethyl)-3-(morpholinocarbonyl)propionic acid, 0.06 ml (0.40 mmoles) of diethyl cyanophosphate, and 0.14 ml (1.00 mmoles) of triethylamine were used, to obtain 205 mg (yield 94%) of the title compound as a white amorphous substance.

Provenance & Evidence