2-Hydroxy-1-(4-methoxyphenyl)-2-phenylethanone → HCID 131717098, compound

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Reaction Conditions

Reaction Steps

A mixture of 4-methoxybenzoin (20 g, 0.083 mole) and succinic anhydride (9.1 g, 0.091 mole) in toluene (6 mL) is heated for 7 hours under nitrogen at 135° C. (internal temp.). The solution is poured into 0.SN-NaHCO3, the organic layer was separated and reextracted with 0.5SN-NaHCO3. The combined extracts are washed with ether and then acidified in the cold with concentrated HCl. The liberated oil is extracted with ethyl acetate (3x), the extracts washed with water and dried (MgSO4). Removal of the solvent yields a yellow solid (20.89 g, 73.8%), m.p. 104°-108° C. It is used in the next step without further purification.

Provenance & Evidence