HCID 24905296, compound → HCID 24905197, compound

Participants

Reaction Conditions

Reaction Steps

1-cyclopentyl-3-(4-ethoxy-3-methoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine (ZK359, 25 mg, 0.071 mmol) was dissolved in CH2Cl2 (5 ml) and stirred at −10° C. under an argon atmosphere. After 30 minutes, reaction was brought to 0° C. and stirred for 2.5 hours. Reaction was stirred for additional 4 hours at room temperature, then concentrated in vacuo and purified by RP-HPLC (MeCN:H2O:0.1% TFA) to yield BA98 (3 mg, 13% yield). ESI-MS (M+H)+ m/z calcd 340.1, found 340.1.

Provenance & Evidence