反应详情

To a suspension of 2-chloro-3-cyano-6-(N,N-dimethylamino)-4-methylpyridine (0.98 g) in acetic acid (10 mL) was added bromine (0.9 g) in acetic acid (1 mL). The reaction mixture was stirred at room temperature for 20 minutes and then warmed to 60° C. for 5 minutes. After cooling to room temperature the mixture was poured into a solution of sodium hydroxide (8 g) in water (100 mL). The mixture was extracted with chloroform (3×30 mL). The combined organic phase was washed, dried, and evaporated to give 1.36 g of the title compound, suitable for use in the next reaction.

1. temperaturewarmed to 60° C. for 5 minutes
2. temperatureAfter cooling to room temperature the mixture
3. extractionThe mixture was extracted with chloroform (3×30 mL)
4. washThe combined organic phase was washed
5. customdried
6. customevaporated