HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Piperidin-2-ylethanol → 5,11-Dihydro-11-ethyl-2-[2-(hydroxyethyl)piperidin-1-yl]-4-methyl-6H-dipyrido[3,2-b:2',3'-e][1,4]diazepin-6-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Piperidin-2-ylethanol | HCID 15144 | — |
| Reactant | Dipyridodiazepinone deriv. 15 | HCID 463144 | — |
| Product | 5,11-Dihydro-11-ethyl-2-[2-(hydroxyethyl)piperidin-1-yl]-4-methyl-6H-dipyrido[3,2-b:2',3'-e][1,4]diazepin-6-one | HCID 53849070 | — |
Reaction Steps
The title compound, m.p. 234°-237° C., was synthesized from 2-chloro-5,11-dihydro-11-ethyl-4 -methyl-6H-dipyrido[3,2-b:2',3'-e][1,4]diazepin-6-one and 2-(hydroxyethyl)piperidine using procedures analogous to those described above, except that the mixture was heated at reflux for 1.25 hrs, and the product was crystallized from ethyl acetate/ethanol.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05366972 |
| Source dataset | uspto-grants-1994_11 |
| ORD ID | ord-61e9920804a24571b57e56976806ef47 |
| Source note | uspto-grants-1994_11 |