Dimethylformamide → HCID 24905240, compound

Participants

Reaction Steps

5-(4-amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-2-fluorobenzonitrile (BA151, 20 mg, 0.07 mmol) was dissolved in DMF (1 ml). t-BuOK (24 mg, 0.21 mmol) was added and the reaction was stirred at room temperature overnight. Reaction was then heated to 150° C. for 24 hours. The reaction was then concentrated in vacuo and purified by RP-HPLC (MeCN:H2O:0.1% TFA) to yield BA157—2 (7 mg), ESI-MS (M+H)+ m/z calcd 295.1, found 295.4 and BA157—3 (8 mg), ESI-MS (M+H)+ m/z calcd 310.1, found 310.4.

Provenance & Evidence