Acetic Anhydride → HCID 18955292, compound

HRID 2380293Notes

Reaction equation

HRID 2380293 reaction equation
C(O[C:5](=[O:7])C)(=O)C.[NH2:8][CH2:9][CH2:10][N:11]1[C:18]2[N:14]([N:15]=[CH:16][CH:17]=2)[CH2:13][CH2:12]1>C(O)=O>[CH:5]([NH:8][CH2:9][CH2:10][N:11]1[C:18]2[N:14]([N:15]=[CH:16][CH:17]=2)[CH2:13][CH2:12]1)=[O:7]

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 18955288HCID 18955288, compound

Product 1

HCID 18955292HCID 18955292, compound

Reagents, catalysts & solvents 1

HCID 284Formic AcidSolvent

Procedure

A mixture of acetic anhydride (4.96 ml) and formic acid (2.51 ml) was stirred for 45 minutes at room temperature. The mixture was cooled to 5° C., and 1-(2-aminoethyl)-2,3-dihydro-1H-imidazo[1,2-b]pyrazole (4.0 g) was added to the mixture. The mixture was stirred for an hour under ice-cooling. The reaction mixture was evaporated and the residue was subjected to column chromatography on silica gel using a mixture of chloroform and methanol (9:1) as an eluent. Fractions containing the object compound were combined and evaporated to give 1-(2-formamidoethyl)-2,3-dihydro-1H-imidazo[1,2-b]pyrazole (2.6 g) as crystals.

Workup

  1. temperatureThe mixture was cooled to 5° C.
  2. stirringThe mixture was stirred for an hour under ice-
  3. temperaturecooling
  4. customThe reaction mixture was evaporated
  5. additiona mixture of chloroform and methanol (9:1) as an eluent
  6. additionFractions containing the object compound
  7. customevaporated

Sources & evidence

ORD record
ord-09866e59367640908bbb559156b57936
Source dataset
uspto-grants-1994_11
Patent number
US05366970

Reaction notes

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