Ammonia → HCID 9948882, compound

HRID 2380312Notes

Reaction equation

HRID 2380312 reaction equation
[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:9]([OH:24])([CH2:18][N:19]1[CH:23]=[N:22][CH:21]=[N:20]1)[C:10]([F:17])([F:16])[C:11](OCC)=[O:12].[NH3:25]>C(O)C>[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:9]([OH:24])([CH2:18][N:19]1[CH:23]=[N:22][CH:21]=[N:20]1)[C:10]([F:17])([F:16])[C:11]([NH2:25])=[O:12]

Participants

4

Reactant 2

HCID 222AmmoniaHCID 19973081HCID 19973081, compound

Product 1

HCID 9948882HCID 9948882, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

In 30 ml of ethanol was dissolved 3.0 g of ethyl 3-(2,4-difluorophenyl)-2,2-difluoro-3-hydroxy-4-(1H-1,2,4-triazol-1-yl)butyrate. To the resulting solution was added 6 ml of concentrated aqueous ammonia. The resulting mixture was subjected to reaction at 20°-25° C. for 5 hours. Then, the solvent was removed by distillation under reduced pressure. The residue obtained was purified by a column chromatography (eluant: chloroform/methanol=20/1) to obtain 2.1 g of 3-(2,4-difluorophenyl)-2,2-difluoro-3-hydroxy-4-(1H-1,2,4-triazol-1-yl)butanamide.

Workup

  1. customThe resulting mixture was subjected to reaction at 20°-25° C. for 5 hours
  2. customThen, the solvent was removed by distillation under reduced pressure
  3. customThe residue obtained
  4. customwas purified by a column chromatography (eluant: chloroform/methanol=20/1)

Sources & evidence

ORD record
ord-df691a7507024842aed9c90f94372cb0
Source dataset
uspto-grants-1994_11
Patent number
US05366989

Reaction notes

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