Ethanol → HCID 10022413, compound

HRID 2380334Notes

Reaction equation

HRID 2380334 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[C:12]([C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)[N:11]=[C:10]([O:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][C:26]([O:28]CC)=[O:27])[CH:9]=2)=[CH:4][CH:3]=1.[OH-].[K+].C(O)C>O>[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[C:12]([C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)[N:11]=[C:10]([O:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][C:26]([OH:28])=[O:27])[CH:9]=2)=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 702EthanolHCID 14797Potassium HydroxideHCID 10431342HCID 10431342, compound

Product 1

HCID 10022413HCID 10022413, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

The procedure in Example 4 is followed but using ethyl 6-{[4-(4-aminophenyl)-6-phenyl-2-pyridyl]-oxy}hexanoate (3.9 g), potassium hydroxide pellets (0.81 g) dissolved in distilled water (10 cc), and ethanol (150 cc). The reaction mixture is refluxed for 2 hours. The product is purified by recrystallization in toluene (70 cc) to obtain 6-{[4-(4-aminophenyl)-6-phenyl-2-pyridyl]oxy}hexanoic acid as yellowish crystals; (m.p.=131°-133° C.)

Workup

  1. temperatureThe reaction mixture is refluxed for 2 hours
  2. customThe product is purified by recrystallization in toluene (70 cc)

Sources & evidence

ORD record
ord-a0e33b5d7cbc4236a9a0d3fd8aaf36fb
Source dataset
uspto-grants-1994_11
Patent number
US05366982

Reaction notes

Loading…