Hydrochloric Acid → HCID 10250881, compound

Participants

Reaction Steps

The mixture comprising methyl 2,2-dimethyl-6-{[4-(4-nitrophenyl)-2-quinolyl]oxy}hexanoate (2.95 g) and dry lithium iodide (6.1 g) in 2,4,6-collidine (115 cc) is refluxed, under inert atmosphere, for 1 hour and 30 minutes and then poured in a 2N solution of hydrochloric acid (150 cc) at 0° C. The aqueous phase is extracted with ethyl ether (3×50 cc). The combined organic phases are washed with distilled water until neutrality, dried over sodium sulphate and then concentrated to dryness under reduced pressure. The residue obtained is purified by chromatography on silica gel (30-60 mm; n-hexane-ethyl acetate 1--1, white solid; m.p.=85°-92° C.)

Provenance & Evidence