Water → HCID 18987245, compound

HRID 2380346Notes

Reaction equation

HRID 2380346 reaction equation
[C:1]1([C:7]2[CH:8]=[C:9]([CH:21]=[C:22]([C:24]3[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=3)[CH:23]=2)[O:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][C:16]([O:18]CC)=[O:17])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[OH-].[K+].O>C(O)C>[C:1]1([C:7]2[CH:8]=[C:9]([CH:21]=[C:22]([C:24]3[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=3)[CH:23]=2)[O:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][C:16]([OH:18])=[O:17])[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

5

Reactant 3

HCID 962WaterHCID 14797Potassium HydroxideHCID 18987360HCID 18987360, compound

Product 1

HCID 18987245HCID 18987245, compoundYield 54%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

By using a similar procedure to that described in example 1 but with 1 g of ethyl 6-(3,5-diphenyl-phenoxy)hexanoate, 0.22 g of potassium hydroxide in pellets, 5 cc of water and 5 cc of ethanol as the starting material (2 hours; reflux), and after recrystallization in a mixture of 10 cc of n-hexane and 2 cc of ethyl acetate, 0.5 g (54%) of 6-(3,5-diphenyl-phenoxy)hexanoic acid was obtained as a white solid. (m.p.=104° C.)

Workup

  1. customafter recrystallization
  2. additionin a mixture of 10 cc of n-hexane and 2 cc of ethyl acetate

Sources & evidence

ORD record
ord-fba6ff9982204656a4dcda4a31971264
Source dataset
uspto-grants-1994_11
Patent number
US05366982

Reaction notes

Loading…