2,4-Di-tert-butylphenol → HCID 9951074, compound

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Reaction Steps

A mixture of 309 g (1.50 mol) of 2,4-di-tert-butylphenol and 196.2 g (1.0 mol) of 4-ethoxymandelic acid is stirred at 140°-150° C. for 2 hours under a nitrogen atmosphere. Stirring at 150° C. is then continued for 1.5 hours under a slight vacuum (50 mbar). Excess 2,4-di-tert-butylphenol is distilled off in a high vacuum. Crystallisation of the residue from 150 ml of xylene and 250 ml of ethanol gives 337.7 g (92%) of 5,7-di-tert-butyl-3-(4-ethoxyphenyl)benzofuran-2-one, melting point 132°-134° C. (compound (101), Table 1).

Provenance & Evidence