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温度

0 °C

Following the procedure of Huckin and Wilson (Can. J. Chem. 1974, p 1346), 850 mg of methyl acetoacetate (7.32 mmol, 1 eq.) were added slowly to a cooled (0° C.) and stirring suspension of NaH (60% dispersion in mineral oil, 1 eq.) in dry THF. When evolution of H2 had ceased (10 min.), 1.05 equivalents of n-butyllithium (2.5M in hexanes) were slowly added, producing an orange solution. After an additional 10 minutes at 0° C., 1 equivalent of 2-fluoro-5-methoxybenzonitrile (1.11 grams, 7.32 mmol) was added dropwise and the resulting red solution was allowed to come to room temperature. After stirring overnight (20 h) the reaction mixture was brought to 0° C. and quenched with 1.5 mL of 12M HCl followed by H2O (20 mL). The mixture was extracted with ether (4×) and the combined ether layers were washed (4×) with saturated aqueous NaCl solution, dried (Na2SO4) and concentrated to give a red oil. Purification via column chromatography (Silica gel, EtOAc/Hexanes eluent) afforded methyl 5-amino-3-oxo-5-(2-fluoro-5-methoxyphenyl)-pent-4-enoate as a pale yellow oil.

1. additionwere added slowly to
2. additionwere slowly added
3. customproducing an orange solution
4. customto come to room temperature
5. stirringAfter stirring overnight (20 h) the reaction mixture
6. customwas brought to 0° C.
7. customquenched with 1.5 mL of 12M HCl
8. extractionThe mixture was extracted with ether (4×)
9. washthe combined ether layers were washed (4×) with saturated aqueous NaCl solution
10. dry with materialdried (Na2SO4)
11. concentrationconcentrated
12. customto give a red oil
13. customPurification via column chromatography (Silica gel, EtOAc/Hexanes eluent)