Methyl iodide → HCID 18955603, compound

HRID 2380409Notes

Reaction equation

[CH3:1][CH:2]1[CH2:7][CH2:6][CH:5]([OH:8])[CH2:4][CH:3]1[C:9]1[CH:14]=[CH:13][CH:12]=[C:11]([O:15][CH2:16][C:17]2[CH:18]=[C:19]3[C:24](=[CH:25][CH:26]=2)[N:23]([CH3:27])[C:22](=[O:28])[CH:21]=[CH:20]3)[CH:10]=1.[CH3:29]I>>[CH3:29][O:8][CH:5]1[CH2:6][CH2:7][CH:2]([CH3:1])[CH:3]([C:9]2[CH:14]=[CH:13][CH:12]=[C:11]([O:15][CH2:16][C:17]3[CH:18]=[C:19]4[C:24](=[CH:25][CH:26]=3)[N:23]([CH3:27])[C:22](=[O:28])[CH:21]=[CH:20]4)[CH:10]=2)[CH2:4]1

Participants

Reactant 2

HCID 6328Methyl iodide

HCID 18955605HCID 18955605, compound

Product 1

HCID 18955603HCID 18955603, compoundYield 60%

Procedure

Using an analogous procedure to that described in Example 2, (1RS,3RS,4SR)-4-methyl-3-[3-(1-methyl-2-oxo-1,2-dihydroquinolin-6-ylmethoxy)phenyl]cyclohexan-1-ol was reacted with methyl iodide to give (1RS,3RS,4SR)-1-methoxy-4-methyl-3-[3-(1-methyl-2-oxo-1,2-dihydroquinolin-6-ylmethoxy)phenyl]cyclohexane as a foam in 60% yield.

Sources & evidence

ORD record: ord-997e641c78554c089b820dc8c3a03798
Source dataset: uspto-grants-1994_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05367079

Reaction notes

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