HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phenylhydrazine → Paclitaxel
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phenylhydrazine | HCID 7516 | — |
| Reactant | Taxol-7-xyloside | HCID 11094265 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | Paclitaxel | HCID 36314 | — |
Reaction Steps
In the manner of the procedure of Example 1, 0.5 g of taxol-7-xyloside was oxidatively cleaved. The product, after treatment with phenylhydrazine, was taken up in 25% acetonitrile in water and applied to a column of 10 g of C-18 reverse phase silica. The column was eluted with a gradient of acetonitrile in water (30, 35, 40, 45, and 50%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05367086 |
| Source dataset | uspto-grants-1994_11 |
| ORD ID | ord-9111c24790c2490f8ebe0374d3ab90f4 |
| Source note | uspto-grants-1994_11 |