Sodium Hydroxide → HCID 21469551, compound

HRID 2380453Notes

Reaction equation

HRID 2380453 reaction equation
[CH2:1]([N:13]1[C:17]([CH:18]([C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)C(OCC)=O)=[N:16][N:15]=[N:14]1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH3:12].[OH-].[Na+]>C(O)C>[CH2:18]([C:17]1[N:13]([CH2:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH3:12])[N:14]=[N:15][N:16]=1)[C:24]1[CH:25]=[CH:26][CH:27]=[CH:28][CH:29]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 10644701HCID 10644701, compound

Product 1

HCID 21469551HCID 21469551, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

(±)-1-Dodecyl-α-phenyl-1H-tetrazole-5-acetic acid, ethyl ester, i.e., the compound of Example 13(c) (14 g; 0.034 mmoles) was dissolved in absolute ethanol (175 mL) and treated with sodium hydroxide pellets (2.7 g; 0.069 mmoles). The solution was stirred for 30 minutes forming a gelatinous precipitate. The solid was removed by filtration, dissolved in water, and then acidified to a pH of 1.0 using concentrated HCl. The precipitate was collected by filtration and washed with water. Yield: 8.5 g (76%), mp 50°-51° C.

Workup

  1. customforming a gelatinous precipitate
  2. customThe solid was removed by filtration
  3. dissolutiondissolved in water
  4. filtrationThe precipitate was collected by filtration
  5. washwashed with water

Sources & evidence

ORD record
ord-fdcf615986a3462dbe76618ab8ea8c59
Source dataset
uspto-grants-1994_11
Patent number
US05366987

Reaction notes

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