Ethyl 2-bromoisovalerate → ethyl (+/-)-5-dodecyl-alpha-(1-methylethyl)-2H-tetrazole-2-acetate
Reaction equation
[CH2:1]([C:13]1[NH:17][N:16]=[N:15][N:14]=1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH3:12].C(C1NN=NN=1)CCCCCCCCC.[CH2:33]([O:35][C:36](=[O:42])[CH:37](Br)[CH:38]([CH3:40])[CH3:39])[CH3:34].BrC1C=CC=CC=1CC(OCC)=O>>[CH2:1]([C:13]1[N:14]=[N:15][N:16]([CH:37]([CH:38]([CH3:40])[CH3:39])[C:36]([O:35][CH2:33][CH3:34])=[O:42])[N:17]=1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH3:12]Participants
5
Procedure
When in the general procedure of Example 71 an appropriate amount of 5-dodecyl-1H-tetrazole was substituted for 5-decyl-1H-tetrazole and an appropriate amount of ethyl-2-bromo-3-methylbutyrate was substituted for ethyl 2-bromophenylacetate, the title compound was obtained.
Sources & evidence
- ORD record
- ord-4e8472d916a745e1b4475f78431fe9ea
- Source dataset
- uspto-grants-1994_11
- Patent number
- US05366987
Reaction notes
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