HCID 18601660, compound → Dihydrocodeine

HRID 2380554Notes

Reaction equation

HRID 2380554 reaction equation
[CH3:1][N:2]1[C@@H:18]2[CH2:19][C:7]3[CH:8]=[CH:9][C:10]([O:21][CH3:22])=[C:11]4[O:12][C@H:13]5[C@@H:14]([OH:20])[CH2:15][CH2:16][C@@H:17]2[C@:5]5([C:6]=34)[CH2:4][CH2:3]1.C(O)(C(O)=O)C(O)C(O)=O>O>[CH3:1][N:2]1[C@@H:18]2[CH2:19][C:7]3[CH:8]=[CH:9][C:10]([O:21][CH3:22])=[C:11]4[O:12][C@H:13]5[C@@H:14]([OH:20])[CH2:15][CH2:16][C@@H:17]2[C@:5]5([C:6]=34)[CH2:4][CH2:3]1

Participants

3

Reactant 1

HCID 18601660HCID 18601660, compound

Product 1

HCID 5284543Dihydrocodeine

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

60.0 g of dihydrocodeine phosphate was dissolved in 600 ml of deionized water, and 378.8 g of Amberlite IRP 69 was added while stirring. The mixture was stirred for 1 hour to yield a dihydrocodeine-resin complex. Then, the complex was treated with PEG and coated with the diffusion barrier material similarly as in Example 1 to obtain a coated dihydrocodeine-resin complex.

Workup

  1. addition378.8 g of Amberlite IRP 69 was added
  2. stirringThe mixture was stirred for 1 hour

Sources & evidence

ORD record
ord-1532b12d8e2d4726b322477ffa0fc545
Source dataset
uspto-grants-1994_11
Patent number
US05368852

Reaction notes

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