Hydrochloric Acid → HCID 178428992, compound

Participants

Reaction Steps

Concentrated hydrochloric acid (0.5 ml) was added to a solution of 2-methyl-4-[1-(2'-(2-triphenylmethyl-2H-tetrazol-5-yl)-biphenyl-4-yl)ethoxy]quinoline (A) (320 mg) in a mixture of ethanol (2 ml) and methanol (1 ml). The solution was left to stand for 3 hours. The precipitated solid was collected by filtration and washed with ether to give 2-methyl-4-[1-(2'-(1H-tetrazol-5-yl)biphenyl-4-yl)ethoxy]quinoline hydrochloride (120 mg), as a white solid, m.p. 168°-169° C.; NMR (d6 -DMSO): 1.8(d, 3H), 2.9(s, 3H), 6.2(q, 1H), 7.2(d, 2H), 7.45(s, 1H), 7.5-7.6(complex m, 4H), 7.65(d, 2H), 7.85(t, 1H), 8.1(t, 1H), 8.2(d, 1H), 8.45(d, 1H); mass spectrum (-ve FAB, DMSO/glycerol (GLY)): 406(M-H)-, 248,158,127; microanalysis, found: C, 66.5; H,5.1; N, 15.8; H2O 2.1%; C25H21N5O.HCl.0.5 H2O requires: C, 66.3; H, 5.1; N, 15.5; 2.0%.

Provenance & Evidence