Acetic Acid → HCID 15729143, compound

Participants

Reaction Steps

A mixture of 2-amino-4-(4-nitrobenzoyl)thiazole g) and 10% palladium on carbon (1 g, 50% wet) in a mixture of tetrahydrofuran (50 ml), methanol (50 ml) and acetic acid (5 ml) was hydrogenated under atmospheric pressure for 7 hours. The reaction mixture was filtered and then, the filtrate was concentrated under reduced pressure. The residue was dissolved in water and adjusted to pH using aqueous sodium bicarbonate. The precipitates were collected by filtration, washed with water and dried in vacuo to give 2-amino-4(4-aminobenzoyl)thiazole (0.54 g, yield: 87.7%).

Provenance & Evidence