Acetic Anhydride → 2-Formylamino-4-(4-formylaminophenylthiomethyl)thiazole

HRID 2380613Notes

Reaction equation

C(O[C:5](=[O:7])C)(=O)C.[CH:8]([NH:10][C:11]1[S:12][CH:13]=[C:14]([CH2:16][S:17][C:18]2[CH:23]=[CH:22][C:21]([NH2:24])=[CH:20][CH:19]=2)[N:15]=1)=[O:9]>C(O)=O>[CH:8]([NH:10][C:11]1[S:12][CH:13]=[C:14]([CH2:16][S:17][C:18]2[CH:23]=[CH:22][C:21]([NH:24][CH:5]=[O:7])=[CH:20][CH:19]=2)[N:15]=1)=[O:9]

Participants

Conditions

Temperature: 50 °C

Procedure

A mixture of acetic anhydride (1.84 g) and formic acid (0.9 g) was heated at 50° C. for 0.5 hours with stirring. The solution was cooled at room temperature ant to the solution was added the 2-formylamino-4-(4-amino-phenylthiomethyl)thiazole (1.6 g). The mixture was stirred at room temperature for 6.5 hours and then the mixture was poured into ice-water. The precipitates were collected by filtration, washed with water and dried in vacuo to give 2-formylamino-4-(4-formylaminophenylthiomethyl)thiazole (1.7 g, yield: 96.7%).

Workup

temperatureThe solution was cooled at room temperature ant to the solution
stirringThe mixture was stirred at room temperature for 6.5 hours
filtrationThe precipitates were collected by filtration
washwashed with water
customdried in vacuo

Sources & evidence

ORD record: ord-c836d46ff5eb4b3f88449c09a15c16c9
Source dataset: uspto-grants-1994_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05369107

Reaction notes

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