Phosphorohydrazidic acid, diethyl ester → HCID 53642074, compound

HRID 2380657Notes

Reaction equation

HRID 2380657 reaction equation
[P:1]([NH:9][NH2:10])(=[O:8])([O:5][CH2:6][CH3:7])[O:2][CH2:3][CH3:4].[Cl:11][C:12]1[CH:19]=[CH:18][C:15]([CH:16]=O)=[C:14]([O:20][CH2:21][C:22](=[CH2:26])[CH:23]([CH3:25])[CH3:24])[CH:13]=1>CCOCC>[Cl:11][C:12]1[CH:19]=[CH:18][C:15]([CH:16]=[N:10][NH:9][P:1](=[O:8])([O:5][CH2:6][CH3:7])[O:2][CH2:3][CH3:4])=[C:14]([O:20][CH2:21][C:22](=[CH2:26])[CH:23]([CH3:24])[CH3:25])[CH:13]=1

Participants

4

Reactant 2

HCID 143340Phosphorohydrazidic acid, diethyl esterHCID 18954847HCID 18954847, compound

Product 1

HCID 53642074HCID 53642074, compoundYield 66.5%

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

To a solution of 11.8 g (0.070 mol) of diethyl phosphorohydrazidate in 140 mL ether was added 14.0 g (0.058 mol) of the product obtained in Step A. The reaction was stirred at room temperature for 30 minutes. The resultant precipitate was filtered and washed with ether (50 mL) and dried to afford 15.0 g of a white solid, mp 103° C. to 106° C.

Workup

  1. filtrationThe resultant precipitate was filtered
  2. washwashed with ether (50 mL)
  3. customdried

Sources & evidence

ORD record
ord-c0e5fd254cda475ea2ed0868200f78cb
Source dataset
uspto-grants-1994_11
Patent number
US05369121

Reaction notes

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