Carbon Tetrachloride → HCID 18954841, compound

Participants

Reaction Steps

To a solution of 2.50 g (0.0054 mol) of 1-(4-chlorophenyl)-5-(4-fluorophenyl)-N-[4-(trifluoromethyl)-phenyl]-1H-pyrazole-3-carboxamide dissolved in 15 mL of acetonitrile was added 1.80 g (0.0067 mol) of triphenylphosphine and 0.83 g (0.0054 mol) of carbon tetrachloride. The yellow solution was stirred at room temperature overnight and concentrated to afford 4.0 g of a yellow solid. The crude product was chromatographed on silica gel using ethyl acetate (10%) and hexanes (90%) as eluents which afforded 0.64 g of a yellow solid, mp 154° C. to 156° C.

Provenance & Evidence