反应详情

A solution of 3.6 g (13.5 mmol) of N-butyl-N-(2'-cyanobiphenyl-4-ylmethyl)-amine and 1.75 g (13.5 mmol) of 2,2-dimethylsuccinic acid anhydride in 50 ml of dioxane is heated under reflux for 5 hours. Concentration of the reaction mixture by evaporation yields crude 3-carboxy-3-methyl-butanoic acid N-butyl-N-(2'-cyanobiphenyl-4-ylmethyl)-amide that melts at from 125° to 131° and is further used in crude form.

1. temperatureunder reflux for 5 hours
2. customConcentration of the reaction mixture by evaporation