Propylamine → N-(2'-cyanobiphenyl-4-ylmethyl)-N-propyl-amine

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Reaction Steps

10.84 g of 4-bromomethyl-2'-cyano-biphenyl are mixed at room temperature with 20 ml of propylamine. The mixture is stirred for 30 minutes, during which heating to reflux temperature occurs, is then diluted with 400 ml of CH2Cl2 and washed with 200 ml of NaHCO3 solution. The organic phase is dried over Na2SO4 and freed of the solvents in vacuo to leave a yellow oil. Purification of the latter by chromatography on silica gel 60 (40-63 μm) using CH2Cl2 /CH3OH (98:2) as eluant yields pure N-(2'-cyanobiphenyl-4-ylmethyl)-N-propyl-amine that has an Rf value of 0.15 [CH2Cl2 /CH3OH (95:5)].

Provenance & Evidence