Potassium Hydroxide → HCID 178457036, compound

Participants

Reaction Steps

A solution of 0.450 g of 4-methoxycarbonyl-4-methyl-pentanoic acid N-propyl-N-[2'-(1H-tetrazol-5-yl)biphenyl-4-ylmethyl]-amide and 2.0 ml of 2N potassium hydroxide solution in 10 ml of methanol is heated under reflux for 6 hours. When cool, the mixture is acidified and concentrated by evaporation. The residue is purified by chromatography on silica gel 60 (40-63 μm) using CH2Cl2 /CH3OH (95:5) as eluant to yield pure 4-carboxy-4-methyl-pentanoic acid N-propyl-N-[2'-(1H-tetrazol-5-yl)biphenyl-4-ylmethyl]-amide that has an Rf value of 0.40 [CH2Cl2 /CH3OH (4:1)].

Provenance & Evidence